Evidence Table

Interactive table for collecting and scoring variant classification evidence. Based on ACMG/AMP guidelines for pathogenicity assessment.

Live Demo

Classification

Uncertain SignificanceScore: 1

Score Range

-9 Benign→0 VUS→+9 Pathogenic

Source	Evidence Type	Score	Notes

-9 to -6Benign

-5 to -2Likely Benign

-1 to 1VUS

2 to 5Likely Pathogenic

6 to 9Pathogenic

Implementation

Usage

import { EvidenceTable } from '@/components/examples/EvidenceTable';

<EvidenceTable />

Features

• Add/remove evidence rows
• Link to external sources
• Score range: -9 (benign) to +9 (pathogenic)
• Automatic classification
• Duplicate type detection
• Only highest score per type counted

Classification Scale

Benign-9 to -6

Likely Benign-5 to -2

Uncertain (VUS)-1 to 1

Likely Pathogenic2 to 5

Pathogenic6 to 9

Evidence Types

• Population Data
• Computational
• Functional Data
• Segregation
• De Novo
• Allelic Data
• Clinical
• Literature

Scoring Rules

• Each evidence type counted once
• Highest absolute score used for duplicates
• Total clamped to -9 to +9 range
• Warnings shown for duplicate types

EvidenceRow Interface

interface EvidenceRow {
  id: string;
  sourceUrl: string;
  sourceTitle: string;
  evidenceType: EvidenceType;
  score: number; // -9 to 9
  notes: string;
}